TSPO Finds NOX2 in Microglia for Redox Homeostasis
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چکیده
منابع مشابه
A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling
The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondria by limiting PARK2-mediated mitochondrial ubiquitination via a peri-organelle accumulation of reactive oxygen species (ROS). Here we describe that...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2016
ISSN: 0165-6147
DOI: 10.1016/j.tips.2016.02.008